A brief history of T cell help to B cells

Nat Rev Immunol. 2015 Mar;15(3):185-9. doi: 10.1038/nri3803. Epub 2015 Feb 13.


In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize and categorize the distinct molecules that are expressed by CD4(+) T cells that constitute 'help' to B cells, and particularly the molecules expressed by T follicular helper (TFH) cells, which are the specialized providers of help to B cells.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Allergy and Immunology / history*
  • B-Lymphocytes / immunology*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • T-Lymphocytes, Helper-Inducer / immunology*