Fecal Microbiota Transplantation for the Management of Clostridium Difficile Infection

Infect Dis Clin North Am. 2015 Mar;29(1):109-22. doi: 10.1016/j.idc.2014.11.009.


This article discusses the use of fecal microbiota transplantation (FMT) for the treatment of recurrent Clostridium difficile infection (CDI). The disruption of the normal gut microbiota is central to the pathogenesis of CDI, and disruption persists in recurrent disease. The use of FMT for recurrent CDI is characterized by a high response rate and short term safety is excellent, although the long-term effects of FMT are as yet unknown.

Keywords: Clostridium difficile; Colitis; Fecal microbiota transplantation; Microbiome; Nonantibiotic treatment; Recurrent C difficile infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Biological Therapy / methods*
  • Clostridium Infections / microbiology
  • Clostridium Infections / therapy*
  • Clostridium difficile*
  • Disease Management
  • Feces / microbiology*
  • Gastrointestinal Tract / microbiology
  • Humans
  • Intestinal Diseases / microbiology*
  • Intestinal Diseases / therapy
  • Microbiota