Broader spectrum of β-thalassemia mutations in Oman: regional distribution and comparison with neighboring countries

Hemoglobin. 2015;39(2):107-10. doi: 10.3109/03630269.2015.1009632. Epub 2015 Feb 13.


The objective of this study was to expand and study the molecular spectrum of β-thalassemia (β-thal) mutations in Oman by examining cases from seven different regions and comparing the prevalence with neighboring countries. A total of 446 cases of β hemoglobinopathies was obtained and analyzed to determine the frequency and distribution of the different β alleles. The molecular spectrum of β-thal in Oman revealed the presence of 32 mutations from different origins and 11 alleles are reported for the first time in the Omani population. The wide heterogeneous spectrum of β-thal mutations found can be associated with the history of trade and migration as well as the past domination from other countries. The presented data will facilitate the development of a comprehensive prevention strategy in Oman.

Keywords: Oman; β Gene mutation spectrum; β-thalassemia (β-thal).

MeSH terms

  • Alleles
  • Exons
  • Gene Frequency
  • Genotype
  • Humans
  • Introns
  • Mutation*
  • Oman / epidemiology
  • beta-Globins / genetics*
  • beta-Thalassemia / epidemiology*
  • beta-Thalassemia / genetics*


  • beta-Globins