Harmonised Australian Reference Intervals for Serum PINP and CTX in Adults

Samuel D Vasikaran; Sa Paul Chubb; Peter R Ebeling; Nicole Jenkins; Graham Rd Jones; Mark A Kotowicz; Howard A Morris; Hans-Gerhard Schneider; Markus J Seibel; Greg Ward

Harmonised Australian Reference Intervals for Serum PINP and CTX in Adults

Clin Biochem Rev. 2014 Nov;35(4):237-42.

Authors

Affiliations

¹ Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth and Fremantle Hospitals, Perth, WA, Australia; ; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA, Australia;
² Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth and Fremantle Hospitals, Perth, WA, Australia; ; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA, Australia; ; School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, Australia;
³ Department of Medicine, School for Clinical Sciences, Faculty Medicine, Dentistry and Health Sciences, Monash University, Clayton, Vic., Australia;
⁴ Clinical Biochemistry Unit, Alfred Pathology Service, Melbourne, Australia;
⁵ Department of Chemical Pathology, SydPath, St Vincent's Hospital, Darlinghurst, NSW, Australia; ; University of NSW, Kensington, NSW, Australia;
⁶ School of Medicine, Deakin University, Geelong, Vic., Australia; ; NorthWest Academic Centre, The University of Melbourne, Sunshine Hospital, St Albans, Vic., Australia; ; Department of Endocrinology & Diabetes, Barwon Health, Geelong, Vic., Australia;
⁷ School of Pharmacy and Medical Sciences, University of South Australia, SA, Australia; ; Chemical Pathology Directorate and Hanson Institute, SA Pathology, Adelaide, SA, Australia;
⁸ Clinical Biochemistry Unit, Alfred Pathology Service, Melbourne, Australia; ; Monash University, Melbourne, Vic., Australia;
⁹ Bone Research Program, ANZAC Research Institute, Sydney, NSW, Australia; ; Department of Endocrinology & Metabolism, Concord Hospital, Sydney, NSW, Australia; ; The University of Sydney, Sydney, NSW, Australia;
¹⁰ Biochemistry & Endocrinology, Sullivan & Nicolaides Pathology, Brisbane, Qld, Australia.

PMID: 25678728
PMCID: PMC4310062

Abstract

Bone turnover markers (BTMs) are classified as either formation or resorption markers. Their concentrations in blood or urine of adults are considered to reflect the rate of bone remodelling and may be of use in the management of patients with bone disease. Major inter-method differences exist for BTMs, and harmonisation of methods is currently being pursued at an international level. Based on published data, this article describes age- and sex-specific Australian consensus reference intervals for adults for serum procollagen type I amino-terminal propeptide (s-PINP) and serum β-isomerised carboxy-terminal cross-linking telopeptide of type I collagen (s-CTX).

Publication types

Review