Fluorescent theranostic agents for Hg(2+) detection and detoxification treatment

Chem Commun (Camb). 2015 Mar 14;51(21):4443-6. doi: 10.1039/c5cc00295h.

Abstract

Two novel fluorescent theranostic agents, 1a and its dimethyl ester 2a, for detection and detoxification of mercury ion poisoning are developed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Survival / drug effects
  • Coumarins / chemistry*
  • Coumarins / pharmacology
  • Dicarboxylic Acids / chemistry*
  • Dicarboxylic Acids / pharmacology
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / pharmacology
  • Humans
  • Ions / chemistry
  • MCF-7 Cells
  • Mercury / analysis*
  • Mercury / toxicity
  • Microscopy, Confocal
  • Spectrophotometry, Ultraviolet
  • Succimer / chemistry
  • Succimer / pharmacology

Substances

  • Coumarins
  • Dicarboxylic Acids
  • Fluorescent Dyes
  • Ions
  • Succimer
  • Mercury