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, 81 (4), 264-8

Clonal Distribution of Multidrug-Resistant Enterobacter Cloacae

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Clonal Distribution of Multidrug-Resistant Enterobacter Cloacae

Delphine Girlich et al. Diagn Microbiol Infect Dis.

Abstract

A multilocus sequence typing (MLST) scheme including 7 housekeeping genes was used to evaluate whether the current spread of multidrug-resistant Enterobacter cloacae isolates worldwide might be associated to specific successful clones. Fifty E. cloacae clinical isolates of worldwide origin, with various β-lactamase content, and recovered at different periods of time were studied. Forty-four sequence types were identified, highlighting a high clonal diversity with 3 main lineages. This study revealed that a precise identification of the isolates by sequencing of the chromosomal ampC gene of E. cloacae would provide a significant added value to improve the reliability of the MLST scheme.

Keywords: Enterobacter cloacae; MLST; Multidrug-resistant bacteria; Prevalence.

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