Genetic Approaches to Facilitate Antibacterial Drug Development

Cold Spring Harb Perspect Med. 2015 Feb 13;5(7):a021139. doi: 10.1101/cshperspect.a021139.


Very few chemically novel agents have been approved for antibacterial chemotherapies during the last 50 yr. Yet new antibacterial drugs are needed to reduce the impact on global health of an increasing number of drug-resistant infections, including highly drug-resistant forms of tuberculosis. This review discusses how genetic approaches can be used to study the mechanism of action of whole-cell screening hits and facilitate target-driven strategies for antimicrobial drug development.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antitubercular Agents / therapeutic use*
  • Drug Design*
  • Humans
  • Mycobacterium tuberculosis / genetics*
  • Tuberculosis / drug therapy*
  • Tuberculosis / microbiology


  • Antitubercular Agents