Small Bowel Bacterial Overgrowth Associated with Persistence of Abdominal Symptoms in Children Treated with a Proton Pump Inhibitor

Agnieszka Sieczkowska; Piotr Landowski; Pawel Zagozdzon; Barbara Kaminska; Carlos Lifschitz

doi:10.1016/j.jpeds.2015.01.004

Small Bowel Bacterial Overgrowth Associated with Persistence of Abdominal Symptoms in Children Treated with a Proton Pump Inhibitor

J Pediatr. 2015 May;166(5):1310-1312.e1. doi: 10.1016/j.jpeds.2015.01.004. Epub 2015 Feb 11.

Authors

Agnieszka Sieczkowska¹, Piotr Landowski², Pawel Zagozdzon³, Barbara Kaminska², Carlos Lifschitz⁴

Affiliations

¹ Department of Pediatrics, Pediatric Gastroenterology, Hepatology, and Nutrition, Medical University of Gdansk, Gdansk, Poland. Electronic address: aszatewicz@gmail.com.
² Department of Pediatrics, Pediatric Gastroenterology, Hepatology, and Nutrition, Medical University of Gdansk, Gdansk, Poland.
³ Department of Hygiene and Epidemiology, Medical University of Gdansk, Gdansk, Poland.
⁴ Section of Pediatric Gastroenterology, Hepatology, and Transplantation, Hospital Italiano, Buenos Aires, Argentina.

PMID: 25681195
DOI: 10.1016/j.jpeds.2015.01.004

Abstract

Small bowel bacterial overgrowth (SBBO) was diagnosed in 22.5% of 40 children treated for 3 months with a proton pump inhibitor (PPI). Compared with those without SBBO, children with SBBO had higher frequency of abdominal pain, bloating, eructation, and flatulence. Patients with gastrointestinal symptoms after PPI treatment should be evaluated for SBBO rather than empirically prolonging PPI therapy.

MeSH terms

Abdominal Pain / diagnosis*
Adolescent
Breath Tests
Child
Child, Preschool
Female
Flatulence
Gastrointestinal Diseases
Humans
Hydrogen / chemistry
Intestine, Small / microbiology*
Male
Microbiota
Prospective Studies
Proton Pump Inhibitors / adverse effects*
Proton Pump Inhibitors / therapeutic use

Substances

Proton Pump Inhibitors
Hydrogen