Small Bowel Bacterial Overgrowth Associated with Persistence of Abdominal Symptoms in Children Treated with a Proton Pump Inhibitor

J Pediatr. 2015 May;166(5):1310-1312.e1. doi: 10.1016/j.jpeds.2015.01.004. Epub 2015 Feb 11.


Small bowel bacterial overgrowth (SBBO) was diagnosed in 22.5% of 40 children treated for 3 months with a proton pump inhibitor (PPI). Compared with those without SBBO, children with SBBO had higher frequency of abdominal pain, bloating, eructation, and flatulence. Patients with gastrointestinal symptoms after PPI treatment should be evaluated for SBBO rather than empirically prolonging PPI therapy.

MeSH terms

  • Abdominal Pain / diagnosis*
  • Adolescent
  • Breath Tests
  • Child
  • Child, Preschool
  • Female
  • Flatulence
  • Gastrointestinal Diseases
  • Humans
  • Hydrogen / chemistry
  • Intestine, Small / microbiology*
  • Male
  • Microbiota
  • Prospective Studies
  • Proton Pump Inhibitors / adverse effects*
  • Proton Pump Inhibitors / therapeutic use


  • Proton Pump Inhibitors
  • Hydrogen