Abstract
WWOX gene is located in FRA16D, the highly affected chromosomal fragile site. Its tumor suppressor activity has been proposed on a basis of numerous genomic alterations reported in chromosome 16q23.3-24.1 locus. WWOX is affected in many cancers, showing as high as 80% loss of heterozygosity in breast tumors. Unlike most tumor suppressors impairing of both alleles of WWOX is very rare. Despite cellular and animal models information on a WWOX role in cancer tissue is limited and sometimes confusing. This review summarizes information on WWOX in human tumors.
Keywords:
WWOX; cancer; tumor suppressor gene.
© 2015 by the Society for Experimental Biology and Medicine.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alleles
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Breast Neoplasms / genetics
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Breast Neoplasms / physiopathology
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Female
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Humans
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Liver Neoplasms / genetics
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Liver Neoplasms / physiopathology
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Loss of Heterozygosity / genetics
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Loss of Heterozygosity / physiology
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Male
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Mutation / genetics
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Mutation / physiology
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Neoplasms / genetics*
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Neoplasms / physiopathology*
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Oxidoreductases / genetics*
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Oxidoreductases / physiology*
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Prostatic Neoplasms / genetics
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Prostatic Neoplasms / physiopathology
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Tumor Suppressor Proteins / genetics*
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Tumor Suppressor Proteins / physiology*
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WW Domain-Containing Oxidoreductase
Substances
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Tumor Suppressor Proteins
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Oxidoreductases
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WW Domain-Containing Oxidoreductase
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WWOX protein, human