Alteration of WWOX in human cancer: a clinical view

Exp Biol Med (Maywood). 2015 Mar;240(3):305-14. doi: 10.1177/1535370214561953. Epub 2015 Feb 13.

Abstract

WWOX gene is located in FRA16D, the highly affected chromosomal fragile site. Its tumor suppressor activity has been proposed on a basis of numerous genomic alterations reported in chromosome 16q23.3-24.1 locus. WWOX is affected in many cancers, showing as high as 80% loss of heterozygosity in breast tumors. Unlike most tumor suppressors impairing of both alleles of WWOX is very rare. Despite cellular and animal models information on a WWOX role in cancer tissue is limited and sometimes confusing. This review summarizes information on WWOX in human tumors.

Keywords: WWOX; cancer; tumor suppressor gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles
  • Breast Neoplasms / genetics
  • Breast Neoplasms / physiopathology
  • Female
  • Humans
  • Liver Neoplasms / genetics
  • Liver Neoplasms / physiopathology
  • Loss of Heterozygosity / genetics
  • Loss of Heterozygosity / physiology
  • Male
  • Mutation / genetics
  • Mutation / physiology
  • Neoplasms / genetics*
  • Neoplasms / physiopathology*
  • Oxidoreductases / genetics*
  • Oxidoreductases / physiology*
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / physiopathology
  • Tumor Suppressor Proteins / genetics*
  • Tumor Suppressor Proteins / physiology*
  • WW Domain-Containing Oxidoreductase

Substances

  • Tumor Suppressor Proteins
  • Oxidoreductases
  • WW Domain-Containing Oxidoreductase
  • WWOX protein, human