MIND diet associated with reduced incidence of Alzheimer's disease

Alzheimers Dement. 2015 Sep;11(9):1007-14. doi: 10.1016/j.jalz.2014.11.009. Epub 2015 Feb 11.

Abstract

Introduction: In a previous study, higher concordance to the MIND diet, a hybrid Mediterranean-Dietary Approaches to Stop Hypertension diet, was associated with slower cognitive decline. In this study we related these three dietary patterns to incident Alzheimer's disease (AD).

Methods: We investigated the diet-AD relations in a prospective study of 923 participants, ages 58 to 98 years, followed on average 4.5 years. Diet was assessed by a semiquantitative food frequency questionnaire.

Results: In adjusted proportional hazards models, the second (hazards ratio or HR = 0.65, 95% confidence interval or CI 0.44, 0.98) and highest tertiles (HR = 0.47, 95% CI 0.26, 0.76) of MIND diet scores had lower rates of AD versus tertile 1, whereas only the third tertiles of the DASH (HR = 0.61, 95% CI 0.38, 0.97) and Mediterranean (HR = 0.46, 95% CI 0.26, 0.79) diets were associated with lower AD rates.

Discussion: High adherence to all three diets may reduce AD risk. Moderate adherence to the MIND diet may also decrease AD risk.

Keywords: Aging; Alzheimer's disease; Cognition; Epidemiological study; Nutrition; diet.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged, 80 and over
  • Alzheimer Disease / diet therapy*
  • Alzheimer Disease / epidemiology*
  • Alzheimer Disease / physiopathology
  • Chicago / epidemiology
  • Cognition Disorders / diet therapy
  • Cognition Disorders / epidemiology
  • Cognition Disorders / physiopathology
  • Diet, Mediterranean*
  • Disease Progression
  • Female
  • Humans
  • Incidence
  • Male
  • Patient Compliance
  • Proportional Hazards Models
  • Prospective Studies
  • Survival Analysis