Prospects for genetically modified non-human primate models, including the common marmoset

Neurosci Res. 2015 Apr;93:110-5. doi: 10.1016/j.neures.2015.01.011. Epub 2015 Feb 12.

Abstract

Genetically modified mice have contributed much to studies in the life sciences. In some research fields, however, mouse models are insufficient for analyzing the molecular mechanisms of pathology or as disease models. Often, genetically modified non-human primate (NHP) models are desired, as they are more similar to human physiology, morphology, and anatomy. Recent progress in studies of the reproductive biology in NHPs has enabled the introduction of exogenous genes into NHP genomes or the alteration of endogenous NHP genes. This review summarizes recent progress in the production of genetically modified NHPs, including the common marmoset, and future perspectives for realizing genetically modified NHP models for use in life sciences research.

Keywords: Common marmoset; Genome editing; Target gene KO; Transgenic.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified / genetics*
  • Callithrix / genetics*
  • Gene Knockout Techniques
  • Models, Animal*
  • Transgenes