FOXP3+ regulatory T cells and their functional regulation

Cell Mol Immunol. 2015 Sep;12(5):558-65. doi: 10.1038/cmi.2015.10. Epub 2015 Feb 16.


FOXP3(+) regulatory T (Treg) cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years. Here, we summarize these intriguing findings, and provide insight into their potential use or manipulation during Treg cell therapy for the treatment of autoimmune diseases, graft-versus-host disease (GVHD) and cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Forkhead Transcription Factors / metabolism*
  • Humans
  • Protein Processing, Post-Translational
  • T-Lymphocytes, Regulatory / immunology*


  • Forkhead Transcription Factors