Comparative effects of ouabain on isolated papillary muscle from tree shrews, guinea-pigs and rats

J Pharm Pharmacol. 1989 Mar;41(3):212-3. doi: 10.1111/j.2042-7158.1989.tb06435.x.

Abstract

Inotropic effects of ouabain were investigated in the isolated papillary muscle preparations of the tree shrew (Tupaia glis), guinea-pigs and rats. In the guinea-pig and shrew papillary muscles, ouabain at concentrations of 10(-8) to 3 x 10(-7) M caused a concentration-dependent positive inotropic response in a similar magnitude, while in the rat, ouabain at concentrations of 10(-7) to 3 x 10(-6) M elicited negative inotropic one. Either phentolamine or pindolol in a concentration sufficient to block the alpha- and beta-adrenoceptors did not antagonize the positive inotropic effect of ouabain in the papillary muscle preparation of the shrews.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Guinea Pigs
  • In Vitro Techniques
  • Myocardial Contraction / drug effects*
  • Ouabain / pharmacology*
  • Papillary Muscles / drug effects
  • Phentolamine / pharmacology
  • Pindolol / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Shrews

Substances

  • Ouabain
  • Pindolol
  • Phentolamine