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Observational Study
. 2015 Nov;11(11):1377-84.
doi: 10.1016/j.jalz.2014.11.007. Epub 2015 Feb 13.

Independent and combined effects of cognitive and physical activity on incident MCI

Tiffany F Hughes  1 , James T Becker  2 , Ching-Wen Lee  3 , Chung-Chou H Chang  4 , Mary Ganguli  5
Affiliations
Observational Study

Independent and combined effects of cognitive and physical activity on incident MCI

Tiffany F Hughes et al. Alzheimers Dement. 2015 Nov.

Abstract

Introduction: The objective of this study was to examine the independent and combined influences of late-life cognitive activity (CA) and physical activity (PA) on the risk of incident mild cognitive impairment (MCI).

Methods: We used interval censored survival modeling to examine the risk of incident MCI (Clinical Dementia Rating [CDR] = 0.5) as a function of CA (high vs. low) and at least moderate intensity PA (any vs. none) among 864 cognitively normal (CDR = 0) older adults.

Results: During three annual follow-up waves, 72 participants developed MCI. Compared with low CA with no PA, significant reductions in risk for MCI were observed for high CA with any PA (hazards ratio (HR) = 0.20, 95% confidence interval (CI) 0.07-0.52) and low CA with any PA (HR = 0.52, 95% CI 0.29-0.93), but not for high CA without PA (HR = 0.94, 95% CI 0.45-1.95).

Discussion: These findings suggest that a combination of CA and PA may be most efficacious at reducing the risk for cognitive impairment.

Keywords: Cognitive activity; Cohort study; Epidemiology; Mild cognitive impairment; Physical activity; observational study.

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Conflict of interest statement

Conflict of Interest Disclosure: None of the authors have any conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow of MYHAT participants into the present analysis
See this image and copyright information in PMC

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