The availability of diltiazem: a study on the sorption by intravenous delivery systems and on the stability of the drug

J Pharm Pharmacol. 1989 Apr;41(4):273-5. doi: 10.1111/j.2042-7158.1989.tb06451.x.

Abstract

The stability and the sorption by intravenous delivery systems of the calcium antagonist diltiazem dissolved into either 5% dextrose or 0.9% sodium chloride solutions have been investigated, under conditions simulating current clinical practice. Static experiments showed an excellent stability and no sorption after 48 h. Dynamic experiments, at a perfusion rate of 20 mg h-1, showed no sorption of the drug by infusion fluid containers, burettes or administration sets. For end-line filters a temporary decrease of the recovered amount of diltiazem was observed but only with the 0.9% NaCl solution. It is concluded that the stability and the sorption of diltiazem offers no problem with regard to clinical efficacy.

MeSH terms

  • Adsorption
  • Biological Availability
  • Chromatography, High Pressure Liquid
  • Diltiazem / administration & dosage
  • Diltiazem / pharmacokinetics*
  • Drug Stability
  • Filtration
  • Infusions, Intravenous
  • Time Factors

Substances

  • Diltiazem