Effect of a Campylobacter pylori protein on acid secretion by parietal cells

Lancet. 1989 Jul 22;2(8656):187-9. doi: 10.1016/s0140-6736(89)90372-3.


The uptake of [14C]-aminopyrine by rabbit gastric epithelial cells was used as an indirect assay for acid secretion from parietal cells. Campylobacter pylori strains, isolated from the stomachs of 3 patients with chronic gastritis, duodenal ulcer, and near-normal mucosa, respectively, inhibited acid secretion as effectively as 10(-4) mol/l cimetidine. The inhibition occurred with whole organisms and with sonicates. Preliminary characterisation suggested that the inhibition was due to a nondialysable protein. The inhibitor was not toxic to gastric epithelial cells. This bacterial product may explain the hypochlorhydria seen in man acutely infected with C pylori.

MeSH terms

  • Aminopyrine
  • Animals
  • Bacterial Proteins / pharmacology*
  • Bacteriological Techniques
  • Campylobacter* / growth & development
  • Carbon Radioisotopes
  • Cimetidine / pharmacology
  • Gastric Acid / metabolism*
  • Male
  • Parietal Cells, Gastric / drug effects*
  • Rabbits


  • Bacterial Proteins
  • Carbon Radioisotopes
  • Aminopyrine
  • Cimetidine