The Serum Immunoglobulin G Glycosylation Signature of Gastric Cancer

EuPA Open Proteom. 2015 Mar 1;6:1-9. doi: 10.1016/j.euprot.2014.11.002.


Biomarkers may facilitate detection of gastric cancer at an earlier stage and reduce mortality. Here we sought to determine if the glycosylation profile of serum immunoglobulin G (IgG) could distinguish patients with non-atrophic gastritis (NAG), duodenal ulcer (DU) and gastric cancer (GC). Serum IgG was released and analyzed using nano-LC-TOF mass spectrometry. Statistically significant false discovery rate (FDR)-adjusted p-values were observed for 18 glycans, eight that differed significantly between NAG and GC, three that distinguished NAG from DU, and eight that differed between DU and GC. The IgG glycosylation signature may be useful as a predictive marker for gastric cancer.

Keywords: Gastric cancer; N-glycan; duodenal ulcer; gastritis; nanoLC-MS; serum.