Abstract
The lipophilic beta-adrenoceptor blocking (BAB) drugs metipranolol, propranolol and exaprolol significantly decreased 48/80- and A23187-induced 32P incorporation into rat mast cell phospholipids. Exaprolol was the most active, followed by propranolol and metipranolol. Atenolol and metipranolol significantly decreased the 48/80-stimulated, and metipranolol and exaprolol the A23187-stimulated 3H-arachidonic acid liberation from isolated mast cells.
MeSH terms
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Adrenergic beta-Antagonists / pharmacology*
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Animals
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Arachidonic Acid
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Arachidonic Acids / metabolism
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Calcimycin / pharmacology
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In Vitro Techniques
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Male
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Mast Cells / drug effects*
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Mast Cells / metabolism
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Phosphates / metabolism
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Phospholipids / metabolism*
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Rats
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Rats, Inbred Strains
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p-Methoxy-N-methylphenethylamine / pharmacology
Substances
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Adrenergic beta-Antagonists
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Arachidonic Acids
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Phosphates
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Phospholipids
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Arachidonic Acid
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Calcimycin
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p-Methoxy-N-methylphenethylamine