Effect of beta-adrenoceptor blocking drugs on 32P incorporation into and arachidonic acid liberation from phospholipids in stimulated rat mast cells

Agents Actions. 1989 Apr;27(1-2):29-32. doi: 10.1007/BF02222189.

Abstract

The lipophilic beta-adrenoceptor blocking (BAB) drugs metipranolol, propranolol and exaprolol significantly decreased 48/80- and A23187-induced 32P incorporation into rat mast cell phospholipids. Exaprolol was the most active, followed by propranolol and metipranolol. Atenolol and metipranolol significantly decreased the 48/80-stimulated, and metipranolol and exaprolol the A23187-stimulated 3H-arachidonic acid liberation from isolated mast cells.

MeSH terms

  • Adrenergic beta-Antagonists / pharmacology*
  • Animals
  • Arachidonic Acid
  • Arachidonic Acids / metabolism
  • Calcimycin / pharmacology
  • In Vitro Techniques
  • Male
  • Mast Cells / drug effects*
  • Mast Cells / metabolism
  • Phosphates / metabolism
  • Phospholipids / metabolism*
  • Rats
  • Rats, Inbred Strains
  • p-Methoxy-N-methylphenethylamine / pharmacology

Substances

  • Adrenergic beta-Antagonists
  • Arachidonic Acids
  • Phosphates
  • Phospholipids
  • Arachidonic Acid
  • Calcimycin
  • p-Methoxy-N-methylphenethylamine