Targeted therapies: DNA polymerase θ-a new target for synthetic lethality?

Nat Rev Clin Oncol. 2015 Mar;12(3):125. doi: 10.1038/nrclinonc.2015.23. Epub 2015 Feb 17.
No abstract available

Publication types

  • Comment

MeSH terms

  • Animals
  • Chromosomes, Mammalian / metabolism*
  • DNA Breaks, Double-Stranded*
  • DNA End-Joining Repair*
  • DNA-Directed DNA Polymerase / metabolism*
  • Female
  • Homologous Recombination*
  • Humans
  • Neoplasms, Glandular and Epithelial / genetics*
  • Neoplasms, Glandular and Epithelial / metabolism*
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / metabolism*
  • Recombination, Genetic*
  • Telomere / genetics*
  • Telomere / metabolism*

Substances

  • DNA-Directed DNA Polymerase