The subthalamic nucleus, oscillations, and conflict

Mov Disord. 2015 Mar;30(3):328-38. doi: 10.1002/mds.26072. Epub 2015 Feb 17.


The subthalamic nucleus (STN), which is currently the most common target for deep brain stimulation (DBS) for Parkinson's disease (PD), has received increased attention over the past few years for the roles it may play in functions beyond simple motor control. In this article, we highlight several of the theoretical, interventional, and electrophysiological studies that have implicated the STN in response inhibition. Most influential among this evidence has been the reported effect of STN DBS in increasing impulsive responses in the laboratory setting. Yet, how this relates to pathological impulsivity in patients' everyday lives remains uncertain.

Keywords: Parkinson's disease; conflict; deep brain stimulation; impulsiveness; subthalamic nucleus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Clocks / physiology*
  • Deep Brain Stimulation / methods
  • Humans
  • Models, Neurological
  • Neural Inhibition / physiology
  • Parkinson Disease / therapy
  • Subthalamic Nucleus / physiology*