Reversal of the novel oral anticoagulants dabigatran, rivoraxaban, and apixaban

Curr Opin Crit Care. 2015 Apr;21(2):127-33. doi: 10.1097/MCC.0000000000000181.


Purpose of review: We summarize the available data related to reversing the anticoagulant effect of the oral direct thrombin and factor Xa inhibitors and provide our opinion on treating patients presenting with severe and life-threatening hemorrhage related to these agents.

Recent findings: No specific antidotes are currently available for the oral direct thrombin and factor Xa inhibitors but two promising agents are under investigation in phase 3 trials. No data are available on reversing these agents in bleeding patients. Activated charcoal may be effective in reducing factor Xa inhibitor absorption up to 6 h after ingestion. Animal models suggest that unactivated 4-factor prothrombin complex concentrate may be an effective reversal agent. Recent data in warfarin-treated patients suggest that 4-factor prothrombin complex concentrate may provide more rapid and effective hemostasis than fresh frozen plasma.

Summary: In the absence of evidence in bleeding patients, animal models and ex-vivo studies suggest administration of coagulant factors in the form of hemostatic agents may be of benefit in reversing the effect of direct thrombin and factor Xa inhibitors. Specific reversal agents and clinical data in patients with hemorrhage remain an unmet need.

Publication types

  • Review

MeSH terms

  • Animals
  • Antidotes / therapeutic use
  • Antithrombins / therapeutic use*
  • Benzimidazoles / therapeutic use*
  • Coagulants / therapeutic use*
  • Dabigatran
  • Factor Xa Inhibitors / therapeutic use
  • Fibrinolytic Agents / therapeutic use
  • Hemorrhage / therapy
  • Humans
  • Models, Animal
  • Morpholines / therapeutic use*
  • Pyrazoles / therapeutic use*
  • Pyridones / therapeutic use*
  • Rivaroxaban
  • Thiophenes / therapeutic use*
  • Thromboembolism / drug therapy
  • beta-Alanine / analogs & derivatives*
  • beta-Alanine / therapeutic use


  • Antidotes
  • Antithrombins
  • Benzimidazoles
  • Coagulants
  • Factor Xa Inhibitors
  • Fibrinolytic Agents
  • Morpholines
  • Pyrazoles
  • Pyridones
  • Thiophenes
  • beta-Alanine
  • apixaban
  • Rivaroxaban
  • Dabigatran