Regulation of lipid production by light-emitting diodes in human sebocytes

Arch Dermatol Res. 2015 Apr;307(3):265-73. doi: 10.1007/s00403-015-1547-1. Epub 2015 Feb 18.


Light-emitting diodes (LED) have been used to treat acne vulgaris. However, the efficacy of LED on sebaceous lipid production in vitro has not been examined. This study investigated the efficacy of 415 nm blue light and 630 nm red light on lipid production in human sebocytes. When applied to human primary sebocytes, 415 nm blue light suppressed cell proliferation. Based on a lipogenesis study using Oil Red O, Nile red staining, and thin-layered chromatography, 630 nm red light strongly downregulated lipid production in sebocytes. These results suggest that 415 nm blue light and 630 nm red light influence lipid production in human sebocytes and have beneficial effects on acne by suppressing sebum production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acne Vulgaris / radiotherapy*
  • Cell Proliferation / radiation effects
  • Cells, Cultured
  • Chromatography, Thin Layer
  • Humans
  • Lasers, Semiconductor / adverse effects
  • Lasers, Semiconductor / therapeutic use*
  • Lipids / biosynthesis*
  • Lipogenesis / radiation effects
  • Low-Level Light Therapy*
  • Primary Cell Culture
  • Sebaceous Glands / pathology
  • Sebum / metabolism*
  • Sebum / radiation effects


  • Lipids