Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis

Lancet. 1989 Jul 29;2(8657):244-7. doi: 10.1016/s0140-6736(89)90430-3.


The effect of tumour necrosis factor (TNF alpha) antibodies on synovial cell interleukin-1 (IL-1) production was investigated in 7 patients with rheumatoid arthritis and in 7 with osteoarthritis. Synovial cell IL-1 production was significantly reduced by anti-TNF alpha antibody in cultures from patients with rheumatoid arthritis, but antilymphotoxin antibody did not have this effect (except in 1 culture). In cultures from patients with osteoarthritis spontaneous IL-1 production was low, despite high concentrations of TNF alpha, and IL-1 production was not inhibited by anti-TNF alpha antibody. In rheumatoid arthritis, TNF alpha may be the main inducer of IL-1, and anti-TNF alpha agents may be useful in treatment.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antilymphocyte Serum / pharmacology
  • Arthritis, Rheumatoid / metabolism*
  • Cells, Cultured
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immune Sera / pharmacology
  • Interleukin-1 / biosynthesis*
  • Interleukin-1 / isolation & purification
  • Male
  • Middle Aged
  • Osteoarthritis / metabolism
  • Synovial Membrane / metabolism*
  • Tumor Necrosis Factor-alpha / physiology*


  • Antilymphocyte Serum
  • Immune Sera
  • Interleukin-1
  • Tumor Necrosis Factor-alpha