Cannabinoids suppress acute and anticipatory nausea in preclinical rat models of conditioned gaping

Clin Pharmacol Ther. 2015 Jun;97(6):559-61. doi: 10.1002/cpt.98. Epub 2015 May 9.


The sensation of nausea is one of the most debilitating human experiences. Current antiemetic therapies are effective in reducing vomiting, but are less effective in reducing acute and delayed nausea and are completely ineffective in reducing anticipatory nausea. Recent preclinical evidence using a selective rat model of nausea (conditioned gaping reactions) has revealed that cannabinoids have great promise as treatments for nausea and that their antinausea effects may be mediated by the interoceptive insular cortex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Animals
  • Cannabidiol / therapeutic use
  • Cannabinoids / therapeutic use*
  • Cerebral Cortex / physiology
  • Disease Models, Animal
  • Nausea / prevention & control*
  • Rats
  • Receptor, Cannabinoid, CB1 / physiology


  • Cannabinoids
  • Receptor, Cannabinoid, CB1
  • Cannabidiol