Nuclear pore proteins and the control of genome functions

Genes Dev. 2015 Feb 15;29(4):337-49. doi: 10.1101/gad.256495.114.


Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules. Beyond this vital role, NPC components influence genome functions in a transport-independent manner. Nups play an evolutionarily conserved role in gene expression regulation that, in metazoans, extends into the nuclear interior. Additionally, in proliferative cells, Nups play a crucial role in genome integrity maintenance and mitotic progression. Here we discuss genome-related functions of Nups and their impact on essential DNA metabolism processes such as transcription, chromosome duplication, and segregation.

Keywords: DNA damage; mitosis; nuclear envelope; nuclear genome; nuclear pore complex; nucleoporin; transcription control.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromosome Duplication / genetics
  • Chromosome Segregation / genetics
  • Gene Expression Regulation
  • Genome*
  • Genomic Instability
  • Humans
  • Nuclear Pore Complex Proteins / genetics
  • Nuclear Pore Complex Proteins / metabolism*


  • Nuclear Pore Complex Proteins