Ribosome-associated ncRNAs: an emerging class of translation regulators

RNA Biol. 2014;11(11):1335-9. doi: 10.1080/15476286.2014.996459.


Accumulating recent evidence identified the ribosome as binding target for numerous small and long non-protein-coding RNAs (ncRNAs) in various organisms of all 3 domains of life. Therefore it appears that ribosome-associated ncRNAs (rancRNAs) are a prevalent, yet poorly understood class of cellular transcripts. Since rancRNAs are associated with the arguable most central enzyme of the cell it seems plausible to propose a role in translation control. Indeed first experimental evidence on small rancRNAs has been presented, linking ribosome association with fine-tuning the rate of protein biosynthesis in a stress-dependent manner.

Keywords: lncRNA; non-coding RNA; ribosome; translation control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Humans
  • Models, Genetic
  • Protein Biosynthesis*
  • RNA, Untranslated / genetics
  • RNA, Untranslated / metabolism*
  • Ribosomes / genetics
  • Ribosomes / metabolism*


  • RNA, Untranslated