CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production

Nat Commun. 2015 Feb 18:6:6217. doi: 10.1038/ncomms7217.


B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influence on the proliferation of B cells, expression of CEACAM1 induces survival of proliferating B cells via the BTK/Syk/NF-κB-axis. The absence of this signalling cascade in naive Ceacam1(-/-) mice limits the survival of B cells. During systemic infection with cytopathic vesicular stomatitis virus, Ceacam1(-/-) mice can barely induce neutralizing antibody responses and die early after infection. We find, therefore, that CEACAM1 is a crucial regulator of B-cell survival, influencing B-cell numbers and protective antiviral antibody responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Neutralizing / immunology
  • Antibodies, Viral / immunology*
  • B-Lymphocytes / cytology*
  • B-Lymphocytes / immunology
  • Bone Marrow / metabolism
  • Bone Marrow Cells / cytology
  • Carcinoembryonic Antigen / physiology*
  • Cell Differentiation
  • Cell Proliferation
  • Cell Separation
  • Cell Survival
  • Flow Cytometry
  • Gene Expression Regulation
  • Immunoglobulin G / immunology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Phosphorylation
  • Signal Transduction
  • Spleen / metabolism
  • Vesiculovirus


  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Carcinoembryonic Antigen
  • Ceacam1 protein, mouse
  • Immunoglobulin G