Identification and management of atypical hemolytic uremic syndrome immediately post-heart transplantation

J Card Surg. 2015 Apr;30(4):373-5. doi: 10.1111/jocs.12520. Epub 2015 Feb 18.

Abstract

Atypical hemolytic uremic syndrome (aHUS) is a serious hematologic disorder with high mortality if left untreated. A comprehensive literature review revealed only two cases of aHUS post-heart transplantation. In both cases the disease developed after induction of calcineurin inhibitor therapy. We report a case of immediate post-heart transplantation aHUS, manifested before the induction of, and therefore not associated with, calcineurin inhibitors.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Monoclonal, Humanized
  • Atypical Hemolytic Uremic Syndrome / diagnosis*
  • Atypical Hemolytic Uremic Syndrome / therapy*
  • Biomarkers / blood
  • Calcineurin Inhibitors
  • Creatinine / blood
  • Dialysis
  • Early Diagnosis
  • Female
  • Haptoglobins
  • Heart Transplantation*
  • Humans
  • L-Lactate Dehydrogenase / blood
  • Plasma Exchange*
  • Platelet Count
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / therapy*
  • Tacrolimus
  • Time Factors
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal, Humanized
  • Biomarkers
  • Calcineurin Inhibitors
  • Haptoglobins
  • eculizumab
  • Creatinine
  • L-Lactate Dehydrogenase
  • Tacrolimus