Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 15 (3), 137-51

Topoisomerase-mediated Chromosomal Break Repair: An Emerging Player in Many Games

Affiliations
Review

Topoisomerase-mediated Chromosomal Break Repair: An Emerging Player in Many Games

Mohamed E Ashour et al. Nat Rev Cancer.

Abstract

The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain DNA and RNA integrity, we know surprisingly little about the mechanisms that underpin the pathology and tissue specificity of many disorders caused by defective responses to DNA or RNA damage. Of the different types of endogenous damage, protein-linked DNA breaks (PDBs) are emerging as an important player in cancer development and therapy. PDBs can arise during the abortive activity of DNA topoisomerases, a class of enzymes that modulate DNA topology during several chromosomal transactions, such as gene transcription and DNA replication, recombination and repair. In this Review, we discuss the mechanisms underpinning topoisomerase-induced PDB formation and repair with a focus on their role during gene transcription and the development of tissue-specific cancers.

Similar articles

See all similar articles

Cited by 55 articles

See all "Cited by" articles

References

    1. J Med Chem. 2012 Oct 25;55(20):8671-84 - PubMed
    1. Curr Cancer Drug Targets. 2006 Nov;6(7):579-602 - PubMed
    1. J Biol Chem. 2001 Dec 7;276(49):46290-6 - PubMed
    1. PLoS Genet. 2014 Sep 18;10(9):e1004630 - PubMed
    1. Phytochem Rev. 2014 Mar 1;13(1):19-35 - PubMed

Publication types

Substances

LinkOut - more resources

Feedback