Lysophosphatidic Acid signaling in the nervous system

Neuron. 2015 Feb 18;85(4):669-82. doi: 10.1016/j.neuron.2015.01.009.


The brain is composed of many lipids with varied forms that serve not only as structural components but also as essential signaling molecules. Lysophosphatidic acid (LPA) is an important bioactive lipid species that is part of the lysophospholipid (LP) family. LPA is primarily derived from membrane phospholipids and signals through six cognate G protein-coupled receptors (GPCRs), LPA1-6. These receptors are expressed on most cell types within central and peripheral nervous tissues and have been functionally linked to many neural processes and pathways. This Review covers a current understanding of LPA signaling in the nervous system, with particular focus on the relevance of LPA to both physiological and diseased states.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Lysophospholipids / metabolism*
  • Nervous System / cytology
  • Nervous System / metabolism*
  • Receptors, G-Protein-Coupled / metabolism
  • Signal Transduction*


  • Lysophospholipids
  • Receptors, G-Protein-Coupled
  • lysophosphatidic acid