Coexistence of GABA and peptide immunoreactivity in non-pyramidal neurons of the basolateral amygdala

Neurosci Lett. 1989 May 22;100(1-3):53-8. doi: 10.1016/0304-3940(89)90659-9.

Abstract

Colocalization of gamma-aminobutyric acid (GABA) immunoreactivity with somatostatin (SOM), neuropeptide Y (NPY), cholecystokinin (CCK), and vasoactive intestinal polypeptide (VIP) immunoreactivity was demonstrated in non-pyramidal neurons of the basolateral amygdala using a two-color immunoperoxidase procedure. Approximately 80-90% of SOM- and NPY-positive neurons in the basolateral amygdala were also immunoreactive for GABA. Virtually all large CCK-positive neurons also exhibited GABA-like immunoreactivity. About one-half of VIP-positive neurons and small CCK-positive cells were also immunoreactive for GABA.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amygdala / cytology
  • Amygdala / metabolism*
  • Animals
  • Cholecystokinin / metabolism
  • Immunohistochemistry
  • Male
  • Neuropeptide Y / metabolism
  • Neuropeptides / metabolism*
  • Rats
  • Rats, Inbred Strains
  • Somatostatin / metabolism
  • Vasoactive Intestinal Peptide / metabolism
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Neuropeptide Y
  • Neuropeptides
  • Vasoactive Intestinal Peptide
  • Somatostatin
  • gamma-Aminobutyric Acid
  • Cholecystokinin