The generation of sex cells

Cell Res. 2015 Mar;25(3):267-8. doi: 10.1038/cr.2015.18. Epub 2015 Feb 20.


Primordial germ cells (PGCs) are the earliest population of germ cells established during embryonic development and constitute the beginning of the totipotent state. A recent study provides a new protocol for the efficient generation of PGC-like cells from human embryonic stem cells, providing an in vitro platform to study human PGC differentiation and specification.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation*
  • Embryonic Stem Cells / cytology*
  • Female
  • Induced Pluripotent Stem Cells / cytology*
  • Male
  • Oocytes / cytology*
  • Ovarian Follicle / cytology*
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / metabolism*