Sinonasal angiosarcoma

Eur Ann Otorhinolaryngol Head Neck Dis. 2015 Jun;132(3):161-3. doi: 10.1016/j.anorl.2015.01.006. Epub 2015 Feb 16.


Introduction: Angiosarcoma is a malignant tumour arising from endothelial cells that accounts for 1% of all sarcomas. The sinonasal site of angiosarcoma is exceptional.

Case report: The authors report a case of sinonasal angiosarcoma in a 53-year-old man. Despite wide resection by open surgery and postoperative chemoradiotherapy, several tumour recurrences were observed, requiring multiple operations.

Discussion: Only histological examination with immunohistochemistry is able to confirm the diagnosis (factor VIII, CD34 and CD31 antigens). Standard treatment consists of surgery with wide resection followed by radiotherapy. The authors discuss the treatment modalities and prognosis of this tumour.

Keywords: Angiosarcoma; Nasal; Radiotherapy; Sinus.

Publication types

  • Case Reports

MeSH terms

  • Chemoradiotherapy / methods
  • Diabetes Mellitus, Type 2 / complications
  • Ethmoid Sinus / pathology*
  • Fatal Outcome
  • Hemangiosarcoma / diagnosis*
  • Hemangiosarcoma / therapy
  • Humans
  • Hypertension / complications
  • Male
  • Middle Aged
  • Natural Orifice Endoscopic Surgery / methods
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local / diagnosis*
  • Neoplasm Recurrence, Local / therapy
  • Neoplasm Staging
  • Paranasal Sinus Neoplasms / diagnosis*
  • Paranasal Sinus Neoplasms / therapy
  • Risk Factors
  • Turbinates / pathology*