The Generation of Antibody-Secreting Plasma Cells

Nat Rev Immunol. 2015 Mar;15(3):160-71. doi: 10.1038/nri3795. Epub 2015 Feb 20.

Abstract

The regulation of antibody production is linked to the generation and maintenance of plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly produced and short-lived effector cells of the early antibody response, whereas plasma cells are the long-lived mediators of lasting humoral immunity. An extraordinary number of control mechanisms, at both the cellular and molecular levels, underlie the regulation of this essential arm of the immune response. Despite this complexity, the terminal differentiation of B cells can be described as a simple probabilistic process that is governed by a central gene-regulatory network and modified by environmental stimuli.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antibodies / immunology*
  • Antibody Formation / immunology
  • B-Lymphocytes / immunology*
  • Cell Differentiation / immunology*
  • Humans
  • Plasma Cells / immunology
  • Plasma Cells / metabolism*

Substances

  • Antibodies