Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus

Biochim Biophys Acta. 2015 Sep;1853(9):1953-7. doi: 10.1016/j.bbamcr.2015.02.008. Epub 2015 Feb 17.


Long-lasting synaptic changes following information acquisition are critical steps for memory. In this process, long-term potentiation (LTP) is widely considered as one of the major cellular mechanisms modifying synaptic strength. It can be classified into early phase LTP (E-LTP) and late phase LTP (L-LTP) based on its duration. Using genetically modified mice, investigators have recognized the critical role of CaMKII in E-LTP and memory. However, its function in L-LTP, which is strongly dependent on gene transcription and protein synthesis, is still unclear. In this review, we discuss how different isoforms of CaMKII are coordinated to regulate gene expression in an activity-dependent manner, and thus contribute to L-LTP and memory. This article is part of a Special Issue entitled: 13th European Symposium on Calcium.

Keywords: CaM translocation; Excitation–transcription coupling; Long-term potentiation (LTP); αCaMKII; βCaMKII; γCaMKII.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism*
  • Cell Nucleus / enzymology*
  • Gene Expression Regulation / physiology
  • Humans
  • Isoenzymes / metabolism
  • Long-Term Potentiation / physiology*
  • Memory / physiology*
  • Mice
  • Protein Biosynthesis / physiology
  • Signal Transduction / physiology*
  • Transcription, Genetic / physiology


  • Isoenzymes
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2