Architectural plan of transcriptional regulation in Mycobacterium tuberculosis

Trends Microbiol. 2015 Mar;23(3):123-5. doi: 10.1016/j.tim.2015.02.002. Epub 2015 Feb 17.


Transcriptional regulation enables adaptation in bacteria. Typically, only a few transcriptional events are well understood, leaving many others unidentified. The recent genome-wide identification of transcription factor binding sites in Mycobacterium tuberculosis has changed this by deciphering a molecular road-map of transcriptional control, indicating active events and their immediate downstream effects.

Keywords: DNA-binding events; gene regulatory network; molecular road-map; transcriptional control.

Publication types

  • Comment

MeSH terms

  • Bacterial Proteins / chemistry*
  • DNA, Bacterial / chemistry*
  • DNA-Binding Proteins / chemistry*
  • Gene Expression Regulation, Bacterial*
  • Mycobacterium tuberculosis / chemistry*


  • Bacterial Proteins
  • DNA, Bacterial
  • DNA-Binding Proteins