Preparation and characterization of quercetin-loaded lipid liquid crystalline systems

A Linkevičiūtė; A Misiūnas; E Naujalis; J Barauskas

doi:10.1016/j.colsurfb.2015.02.001

Preparation and characterization of quercetin-loaded lipid liquid crystalline systems

Colloids Surf B Biointerfaces. 2015 Apr 1:128:296-303. doi: 10.1016/j.colsurfb.2015.02.001. Epub 2015 Feb 9.

Authors

A Linkevičiūtė¹, A Misiūnas², E Naujalis³, J Barauskas⁴

Affiliations

¹ Department of Analytical and Environmental Chemistry, Vilnius University, Naugarduko 24, LT-03225 Vilnius, Lithuania; State Research Institute, Center for Physical Sciences and Technology, A. Goštauto 11, LT-01108 Vilnius, Lithuania. Electronic address: ausra.linkeviciute@ftmc.lt.
² State Research Institute, Center for Physical Sciences and Technology, A. Goštauto 11, LT-01108 Vilnius, Lithuania. Electronic address: audrius_misiunas@yahoo.com.
³ Department of Analytical and Environmental Chemistry, Vilnius University, Naugarduko 24, LT-03225 Vilnius, Lithuania; State Research Institute, Center for Physical Sciences and Technology, A. Goštauto 11, LT-01108 Vilnius, Lithuania. Electronic address: naujalis@pfi.lt.
⁴ Biomedical Science, Faculty of Health and Society, Malmö University, SE-20506 Malmö, Sweden. Electronic address: justas.barauskas@mah.se.

PMID: 25701115
DOI: 10.1016/j.colsurfb.2015.02.001

Abstract

The aim of the present study was to investigate mixtures of soy phosphatidylcholine (SPC) and glycerol dioleate (GDO) as encapsulation matrices for antioxidant quercetin. The effects of quercetin loading into non-aqueous formulations, non-lamellar liquid crystalline phases and their colloidal dispersions were studied by using synchrotron small angle X-ray diffraction, dynamic light scattering, cryogenic electron microscopy and high performance liquid chromatography. Quercetin incorporation is discussed in the context of lipid aggregation behavior, self-assembled nanostructure and chemical stability. The obtained results show that SPC/GDO-based formulations can incorporate relatively high amounts of quercetin and serve as liquid crystalline delivery vehicles in the form of bulk phases or colloidal dispersions.

Keywords: Lipid liquid crystalline nanoparticles; Lipid liquid crystals; Non-lamellar phases; Quercetin; Small angle X-ray diffraction; cryo-TEM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cryoelectron Microscopy
Diglycerides / chemistry*
Drug Carriers
Drug Compounding
Liquid Crystals / chemistry*
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Particle Size
Phosphatidylcholines / chemistry*
Quercetin / chemistry*

Substances

Diglycerides
Drug Carriers
Phosphatidylcholines
Quercetin
diolein