Enteric hyperoxaluria: an important cause of end-stage kidney disease

Nephrol Dial Transplant. 2016 Mar;31(3):375-82. doi: 10.1093/ndt/gfv005. Epub 2015 Feb 20.


Hyperoxaluria is a frequent complication of inflammatory bowel diseases, ileal resection and Roux-en-Y gastric bypass and is well-known to cause nephrolithiasis and nephrocalcinosis. The associated prevalence of chronic kidney disease and end-stage kidney disease (ESKD) is less clear but may be more consequential than recognized. In this review, we highlight three cases of ESKD due to enteric hyperoxaluria following small bowel resections. We review current information on the pathophysiology, complications and treatment of this complex disease.

Keywords: inflammatory bowel disease; kidney stones; oxalate; transplantation; urolithiasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Humans
  • Hyperoxaluria / complications*
  • Kidney Failure, Chronic / etiology*
  • Urolithiasis / complications*