Sortilin, encoded by the cardiovascular risk gene SORT1, and its suggested functions in cardiovascular disease

Curr Atheroscler Rep. 2015 Apr;17(4):496. doi: 10.1007/s11883-015-0496-7.


Several genome-wide association studies have linked novel loci to a wide range of cardiovascular phenotypes including low-density lipoprotein (LDL)-cholesterol, early onset myocardial infarction, coronary artery calcification, coronary artery stenosis, and abdominal aorta aneurysm. Especially, one locus, namely, 1p13.3, has attracted much attention. This locus harbors four candidate genes, CELSR2, PSRC1, MYBPHL, and SORT1. SORT1 encodes sortilin, a type I sorting receptor that has recently been implicated in LDL-cholesterol metabolism, VLDL secretion, PCSK9 secretion, and development of atherosclerotic lesions. Furthermore, sortilin also seems to be involved in the development of atherosclerosis, by mechanisms not directly involving LDL-cholesterol, but possibly resulting from the attenuated secretion of proinflammatory cytokines, such as IL6 and TNFα, which accompanies lack of sortilin in immune cells. Sortilin seems to play an important role in the development of cardiovascular disease and have functions beyond regulating LDL-cholesterol.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Vesicular Transport / genetics*
  • Adaptor Proteins, Vesicular Transport / immunology
  • Adaptor Proteins, Vesicular Transport / metabolism
  • Atherosclerosis / genetics*
  • Atherosclerosis / immunology
  • Atherosclerosis / metabolism
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / immunology
  • Cardiovascular Diseases / metabolism
  • Cholesterol, LDL / metabolism
  • Coronary Artery Disease / genetics*
  • Coronary Artery Disease / immunology
  • Coronary Artery Disease / metabolism
  • Genome-Wide Association Study
  • Humans
  • Interleukin-6 / immunology
  • Lipid Metabolism / genetics
  • Lipid Metabolism / immunology
  • Lipoproteins, VLDL / metabolism
  • Proprotein Convertase 9
  • Proprotein Convertases / metabolism
  • Serine Endopeptidases / metabolism
  • Tumor Necrosis Factor-alpha / immunology


  • Adaptor Proteins, Vesicular Transport
  • Cholesterol, LDL
  • IL6 protein, human
  • Interleukin-6
  • Lipoproteins, VLDL
  • Tumor Necrosis Factor-alpha
  • PCSK9 protein, human
  • Proprotein Convertase 9
  • Proprotein Convertases
  • Serine Endopeptidases
  • sortilin