Butyrolactones derivatives from the fermentation products of a plant entophytic fungus Penicillium oxalicum

Nat Prod Res. 2015;29(20):1914-9. doi: 10.1080/14786419.2015.1013473. Epub 2015 Feb 23.

Abstract

Two new butyrolactone derivatives, terrelactones A and B (1 and 2), together with four known butyrolactone derivatives (3-6), were isolated from the fermentation products of the fungus Penicillium oxalicum 0403. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1 and 2 were evaluated. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 25.5% and 27.4%, respectively. The inhibition rate is close to that of positive control (28.9%).

Keywords: Penicillium oxalicum 0403; anti-TMV activities; butyrolactone derivatives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Butyrolactone / analogs & derivatives
  • 4-Butyrolactone / chemistry
  • 4-Butyrolactone / isolation & purification
  • Antiviral Agents / chemistry*
  • Antiviral Agents / isolation & purification
  • Fermentation
  • Lactones / chemistry*
  • Lactones / isolation & purification
  • Molecular Structure
  • Penicillium / chemistry*
  • Tobacco Mosaic Virus / drug effects*

Substances

  • Antiviral Agents
  • Lactones
  • terrelactone A
  • terrelactone B
  • 4-Butyrolactone