Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia

Sivaraman Purushothuman; Daniel M Johnstone; Charith Nandasena; Janet van Eersel; Lars M Ittner; John Mitrofanis; Jonathan Stone

doi:10.1016/j.neulet.2015.02.037

Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia

Neurosci Lett. 2015 Mar 30:591:155-159. doi: 10.1016/j.neulet.2015.02.037. Epub 2015 Feb 19.

Authors

Sivaraman Purushothuman¹, Daniel M Johnstone², Charith Nandasena³, Janet van Eersel⁴, Lars M Ittner⁵, John Mitrofanis⁶, Jonathan Stone³

Affiliations

¹ Bosch Institute, University of Sydney, NSW 2006, Australia; Discipline of Physiology, University of Sydney, NSW 2006, Australia; Save Sight Institute & Clinical Ophthalmology, University of Sydney & Sydney Eye Hospital, NSW 2000, Australia.
² Bosch Institute, University of Sydney, NSW 2006, Australia; Discipline of Physiology, University of Sydney, NSW 2006, Australia. Electronic address: Daniel.Johnstone@sydney.edu.au.
³ Bosch Institute, University of Sydney, NSW 2006, Australia; Discipline of Physiology, University of Sydney, NSW 2006, Australia.
⁴ Dementia Research Unit, School of Medical Sciences, University of New South Wales, NSW 2052, Australia.
⁵ Dementia Research Unit, School of Medical Sciences, University of New South Wales, NSW 2052, Australia; Neuroscience Research Australia, Sydney, NSW 2031, Australia.
⁶ Bosch Institute, University of Sydney, NSW 2006, Australia; Discipline of Anatomy & Histology, University of Sydney, NSW 2006, Australia.

PMID: 25703226
DOI: 10.1016/j.neulet.2015.02.037

Abstract

We previously reported that Alzheimer-related pathology in cerebral cortex of APP/PS1 and K3 tau transgenic mouse strains is mitigated by near infrared light (NIr). Here, we extend these observations to the cerebellum. One month of NIr treatment mitigated the deposition of β-amyloid in cerebellar cortex of APP/PS1 mice, and the formation of neurofibrillary tangles, the hyperphosphorylation of tau, the damage caused by oxidative stress and the downregulation of cytochrome oxidase expression by Purkinje cells in the cerebellar cortex of K3 mice. These findings show the ability of NIr to mitigate degeneration in many - probably all - regions of the mouse brain.

Keywords: Dementia; Mouse model; Near infrared light; Neuroprotection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amyloid beta-Protein Precursor / genetics
Animals
Cerebellum / metabolism
Cerebellum / pathology
Cerebellum / radiation effects*
Dementia / metabolism
Dementia / pathology
Dementia / prevention & control*
Disease Models, Animal
Infrared Rays*
Low-Level Light Therapy
Mice, Transgenic
Mitochondria / metabolism
Oxidative Stress
Plaque, Amyloid / pathology
Presenilin-1 / genetics
tau Proteins / genetics

Substances

Amyloid beta-Protein Precursor
Presenilin-1
tau Proteins