Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos

Nature. 1989 Sep 7;341(6237):33-8. doi: 10.1038/341033a0.


The expression of the Xenopus homoeobox gene xhox3 is an early response to mesoderm induction by peptide growth factors and the level of xhox3 expression marks the antero-posterior character of the induced mesoderm. Different peptide growth factors specify different antero-posterior mesodermal cell fates as seen by the level of xhox3 expression and the capacity to induce specific secondary neural/epidermal structures. These factors and homoeobox genes thus form part of the mechanism necessary for establishing antero-posterior polarity in the frog embryo.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Differentiation*
  • Embryonic Induction*
  • Gene Expression Regulation
  • Genes, Homeobox*
  • Growth Substances / physiology*
  • Mesoderm / physiology
  • Morphogenesis
  • RNA, Messenger / genetics
  • Xenopus laevis / embryology*


  • Growth Substances
  • RNA, Messenger