doi: 10.3109/19401736.2015.1007332.
Epub 2015 Feb 23.
The role of mitochondrial tRNA variants in female breast cancer
Affiliations
- PMID: 25703847
- DOI: 10.3109/19401736.2015.1007332
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The role of mitochondrial tRNA variants in female breast cancer
Mitochondrial DNA A DNA Mapp Seq Anal.
2016 Sep.
Abstract
Mitochondrial tRNA (Mt-tRNA) variants have been found to be involved in the carcinogenesis of breast cancer. These tRNAs, which played critical roles in mitochondrial protein synthesis, were important regulators in tumorigenesis. Distinguishing the polymorphisms or mutations in mt-tRNA genes was still puzzling for the clinicians and geneticists when confronted with the breast cancer. In this study, we performed a detailed analysis of recently reported mutations in mt-tRNA genes and further discussed the relationship between these variants and breast cancer.
Keywords: Breast cancer; mitochondrial tRNA; mutations; polymorphisms; risk factor.
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