Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 May;76:242-53.
doi: 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20.

Hericium Erinaceus Polysaccharide-Protein HEG-5 Inhibits SGC-7901 Cell Growth via Cell Cycle Arrest and Apoptosis

Affiliations

Hericium Erinaceus Polysaccharide-Protein HEG-5 Inhibits SGC-7901 Cell Growth via Cell Cycle Arrest and Apoptosis

Xinyi Zan et al. Int J Biol Macromol. .

Abstract

HEG-5 is a novel polysaccharide-protein purified from the fermented mycelia of Hericium erinaceus CZ-2. The present study aims to investigate the effects of HEG-5 on proliferation, cell cycle and apoptosis of human gastric cancer cells SGC-7901. Here, we first uncover that HEG-5 significantly inhibited the proliferation and colony formation of SGC-7901 cells by promoting apoptosis and cell cycle arrest at S phase. RT-PCR and Western blot analysis suggested that HEG-5 could decrease the expressions of Bcl2, PI3K and AKT1, while increase the expressions of Caspase-8, Caspase-3, p53, CDK4, Bax and Bad. These findings indicated that the Caspase-8/-3-dependent, p53-dependent mitochondrial-mediated and PI3k/Akt signaling pathways involved in the molecular events of HEG-5 induced apoptosis and cell cycle arrest. Thus, our study provides in vitro evidence that HEG-5 may be taken as a potential candidate for treating gastric cancer.

Keywords: Anti-tumor activity; Apoptosis; Cell cycle; Hericium erinaceus; Polysaccharide-protein.

Similar articles

See all similar articles

Cited by 9 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback