EVpedia: A community web resource for prokaryotic and eukaryotic extracellular vesicles research

Semin Cell Dev Biol. 2015 Apr;40:4-7. doi: 10.1016/j.semcdb.2015.02.005. Epub 2015 Feb 19.


For cell-to-cell communication, all living cells including archaea, bacteria, and eukaryotes secrete nano-sized membrane vesicles into the extracellular space. These extracellular vesicles harbor specific subsets of proteins, mRNAs, miRNAs, lipids, and metabolites that represent their cellular status. These vesicle-specific cargos are considered as novel diagnostic biomarkers as well as therapeutic targets. With the advancement in high-throughput technologies on multiomics studies and improvements in bioinformatics approaches, a huge number of vesicular proteins, mRNAs, miRNAs, lipids, and metabolites have been identified, and our understanding of these complex extracellular organelles has considerably increased during these past years. In this review, we highlight EVpedia (http://evpedia.info), a community web portal for systematic analyses of prokaryotic and eukaryotic extracellular vesicles research.

Keywords: Communicasomes; Ectosomes; Exosomes; Microvesicles; Nanocosmos; Outer membrane vesicles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomedical Research
  • Eukaryota / cytology*
  • Eukaryota / metabolism
  • Extracellular Vesicles / chemistry*
  • Extracellular Vesicles / metabolism
  • Information Storage and Retrieval
  • Internet
  • Prokaryotic Cells / cytology*
  • Prokaryotic Cells / metabolism