DNA-ligand interactions gained and lost: light-induced ligand redistribution in a supramolecular cascade

Chem Commun (Camb). 2015 Mar 21;51(23):4906-9. doi: 10.1039/c5cc01025j.

Abstract

A supramolecular five-component cascade is presented that enables light-controlled transport of an in situ modified ligand between three host systems based on the different complexation preferences of cyclodextrin, cucurbituril, and double-stranded DNA. The results point out novel approaches for the control of drug-DNA interactions in DNA-targeting therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclodextrins / chemistry*
  • DNA / chemistry*
  • DNA / radiation effects*
  • Drug Carriers
  • Drug Delivery Systems
  • Drug Liberation
  • Ligands
  • Light*
  • Macrocyclic Compounds / chemistry*
  • Macromolecular Substances

Substances

  • Cyclodextrins
  • Drug Carriers
  • Ligands
  • Macrocyclic Compounds
  • Macromolecular Substances
  • cucurbit(n)uril
  • DNA