Is there a role of adjuvant treatment for salivary duct carcinoma?

J Laryngol Otol. 2015 Mar;129 Suppl 2:S98-101. doi: 10.1017/S0022215114002965.

Abstract

Objective: To determine the clinical effect of post-operative radiotheraphy and systemic chemotherapy for the treatment of salivary duct carcinoma.

Study design: Retrospective review.

Design: The medical records of 26 patients treated by surgery with or without radiotheraphy and/or systemic chemotherapy for salivary duct carcinoma were retrospectively reviewed to investigate the role of post-operative adjuvant treatment for the patients' prognosis.

Results: The overall three-year and five-year survival rates were 54 and 48.1 per cent, respectively. There was no correlation with the clinical stage and the patients' prognosis. The overall three-year survival of the patients with or without post-operative radiotheraphy was 64 and 33 per cent, respectively (p = 0.29). The overall three-year survival of the patients with or without post-operative chemotherapy was 53 and 56 per cent, respectively (p = 0.78).

Conclusion: Post-operative adjuvant therapy did not improve the patients' overall prognosis with salivary duct carcinoma. Developing novel treatment modalities may be necessary to improve the prognosis of this aggressive disease.

Keywords: Adjuvant treatment.

MeSH terms

  • Carcinoma, Squamous Cell / therapy*
  • Chemoradiotherapy, Adjuvant / mortality*
  • Head and Neck Neoplasms / therapy*
  • Humans
  • Neoplasm Staging
  • Prognosis
  • Retrospective Studies
  • Salivary Ducts*
  • Salivary Gland Neoplasms / therapy*
  • Squamous Cell Carcinoma of Head and Neck
  • Survival Rate