Applanatumin A, a new dimeric meroterpenoid from Ganoderma applanatum that displays potent antifibrotic activity

Org Lett. 2015 Mar 6;17(5):1110-3. doi: 10.1021/ol503610b. Epub 2015 Feb 23.


Applanatumin A (1), a novel meroterpenoid dimer, was isolated from the fungus Ganoderma applanatum. Its structure and absolute configuration were assigned on the basis of spectroscopic and computational data. Notably, 1 possesses a new hexacyclic skeleton containing a spiro[benzofuran-2,1'-cyclopentane] motif. A plausible pathway, involving a key Diels-Alder reaction, is proposed for the biosynthesis of 1. Applanatumin A exhibits potent antifibrotic activity in TGF-β1-induced human renal proximal tubular cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cycloaddition Reaction
  • Fibrosis / prevention & control
  • Ganoderma / chemistry*
  • Humans
  • Molecular Structure
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology*
  • Transforming Growth Factor beta1 / pharmacology


  • Terpenes
  • Transforming Growth Factor beta1
  • applanatumin A