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. 2015 Mar 11;137(9):3201-4.
doi: 10.1021/jacs.5b00216. Epub 2015 Feb 25.

Rhodium-catalyzed Asymmetric Arylation of Allyl Sulfones Under the Conditions of Isomerization Into Alkenyl Sulfones

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Rhodium-catalyzed Asymmetric Arylation of Allyl Sulfones Under the Conditions of Isomerization Into Alkenyl Sulfones

Kelvin Meng-Hui Lim et al. J Am Chem Soc. .

Abstract

The reaction of 3-sulfolene with arylboronic acids in the presence of a chiral diene-rhodium catalyst under highly basic conditions (10 equiv of KOH) gave high yields of 3-arylsulfolanes with high enantioselectivity, where 3-sulfolene is in equilibration with 2-sulfolene by base-catalyzed isomerization and the more reactive 2-sulfolene undergoes the rhodium-catalyzed asymmetric arylation.

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