Murine enterocytes can present soluble antigen to specific class II-restricted CD4+ T cells

Eur J Immunol. 1989 Aug;19(8):1513-6. doi: 10.1002/eji.1830190827.


Highly purified mature epithelial cells (EC) from murine small intestinal villi (excluding Peyer's patch epithelium) were examined for their capacity to present foreign antigen to T cells. Cell suspensions composed of 99% Ia+T200- EC were able to present keyhole limpet hemocyanin to an antigen-specific class II-restricted L3T4+ T cell hybridoma, and stimulate interleukin 2 production. Antigen presentation by EC was inhibited by major histocompatibility complex class II-specific monoclonal antibodies. It is concluded that EC express functional class II molecules and may activate adjacent CD4+ T cells to induce lymphokine synthesis.

MeSH terms

  • Animals
  • Antigen-Antibody Reactions
  • Antigen-Presenting Cells / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • H-2 Antigens / immunology
  • Histocompatibility Antigens Class II / immunology*
  • Hybridomas
  • Interleukin-2 / biosynthesis
  • Intestinal Mucosa / immunology*
  • Mice
  • T-Lymphocytes, Helper-Inducer / immunology*


  • H-2 Antigens
  • Histocompatibility Antigens Class II
  • Interleukin-2